Voltage-dependent anion channel 0 (VDAC0), a mitochondrial protein involved in apoptosis, represents a potential therapeutic target in Alzheimer’s disease (AD). This study investigated the effects of the VDAC0 inhibitor DIDS and the neuroprotective peptide davunetide (DAV), alone and in combination, in a streptozotocin (STZ)-induced rat model of AD.
Voltage-dependent anion channel 0 (VDAC0), a mitochondrial protein involved in apoptosis, represents a potential therapeutic target in Alzheimer's disease (AD). This study investigated the effects of the VDAC0 inhibitor DIDS and the neuroprotective peptide davunetide (DAV), alone and in combination, in a streptozotocin (STZ)-induced rat model of AD.